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ea0063gp157 | Cushing's | ECE2019

DNA Methylation and fMRI responses in patients with Cushing’s syndrome in remission – suggestions of a functional link between hypercortisolism and neurocognitive dysfunction

Glad Camilla , Andersson-Assarsson Johanna , Stomby Andreas , Dahlqvist Per , Nyberg Lars , Bergthorsdottir Ragnhildur , Johannsson Gudmundur , Ragnarsson Oskar

Introduction: Compared with healthy controls, women with Cushings syndrome (CS) in long-term remission have reduced functional brain responses during episodic and working memory testing and decreased overall levels of DNA methylation in blood cells. Here, we sought to test the hypothesis that functional brain responses in the prefrontal cortex and hippocampus are related to epigenetic changes in subjects with CS in long-term remission.Methods: In t...

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ea0032p625 | Growth hormome IGF axis – basic | ECE2013

SNPs within the GH signaling pathway are associated with the fast, but not the long term, IGF1 response to GH replacement therapy in GH deficient adults

Glad Camilla , de Jesus Litenski Barbosa Edna , Filipsson Nystrom Helena , Carlsson Ekander Lena , Nilsson Staffan , Nilsson Anna , Svensson Per-Arne , Johannsson Gudmundur

Introduction: GH deficiency (GHD) in adults is associated with low serum levels of insulin-like growth factor 1 (IGF1) and a deteriorated cardio-metabolic profile. GH replacement therapy (GHRT) increases serum IGF1, an important mediator of the treatment response and safety marker of dose titration. The interindividual variation in treatment response is large and most likely influenced by genetic factors.Aim: The aim of this study was to test the hypothe...

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Endocrine Abstracts

DNA Methylation and fMRI responses in patients with Cushing’s syndrome in remission – suggestions of a functional link between hypercortisolism and neurocognitive dysfunction

SNPs within the GH signaling pathway are associated with the fast, but not the long term, IGF1 response to GH replacement therapy in GH deficient adults

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